Abstract
IT has been postulated that a change in amine concentrations in the brain is causally related to the activity of a drug in the central nervous system. In 1940, Mann and Quastel1 suggested that the central stimulant activity of ‘Benzedrine’ was related to its ability to inhibit the oxidation of tyramine by amine oxidase. Fellows and Bernheim2 observed an excellent correlation between the increased motor activity in the rat and the inhibition of amine oxidase by a series of aryl-2-aminopropane derivatives. Recently, Tedeschi et al. 3 observed that SKF No. 385, 2-phenylcyclopropylamine, in the rabbit, demonstrated an activity suggestive of in vivo monoamine oxidase inhibition. Since this compound was not a hydrazine, it was decided to study its effect on amine oxidase activity.
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References
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MAASS, A., NIMMO, M. A New Inhibitor of Serotonin Metabolism. Nature 184, 547–548 (1959). https://doi.org/10.1038/184547b0
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DOI: https://doi.org/10.1038/184547b0
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