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Incorporation of 5-Bromouracil into Transforming Principle of Bacillus subtilis and its Biological Effects

Nature volume 184, pages 472–473 (1959)Cite this article

Abstract

THE incorporation of 5-bromouracil into deoxyribonucleic acids of bacteria and bacteriophage1 raised a problem concernnig the biological effects of such incorporation. It has been shown that at least some of the cells of Escherichia coli containing 5-bromouracil in their deoxyribonucleic acid remain alive2. Further evidence on this subject was obtained by the demonstration of the mutagenic effect of 5-bromouracil3; these results also indicated that 5-bromouracil was incorporated into molecules of deoxyribonucleic acid that functioned as heredity determinants. Similar results have been obtained with bacteriophage.4

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Authors and Affiliations

  1. Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, 32

    ERELA EPHRATI-ELIZUR & STEPHEN ZAMENHOF

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  1. ERELA EPHRATI-ELIZUR
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  2. STEPHEN ZAMENHOF
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EPHRATI-ELIZUR, E., ZAMENHOF, S. Incorporation of 5-Bromouracil into Transforming Principle of Bacillus subtilis and its Biological Effects. Nature 184, 472–473 (1959). https://doi.org/10.1038/184472a0

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