Abstract
IT has been shown recently by Brown and his co-workers1 that when digitoxin was administered to rats or to adult humans some of it underwent hydroxylation at C12 to give digoxin. This fact, suggestive of the possibility of such bioconversions to be effected by micro-organisms as well, prompted us to investigate microbiological transformation of the cardiac glycosides and their aglycones. In this communication we wish to report that the C12- and C16- hydroxylations of digitoxigenin.
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References
Brown, B. T., Wright, S. E., and Okita, G. T., Nature, 180, 607 (1957). Later, K., Repke also obtained the same results, Naturwiss., 45, 94, 366 (1958).
Sasakawa, Y., Yakugaku Zasshi, 75, 946 (1955).
Jensen, K. B., and Tennöe, K., J. Pharm. Pharmacol., 7, 334 (1955).
Tschesche, R., Grimmer, G., and Seehofer, F., Chem. Ber., 86, 1235 (1953).
Gubler, A., and Tamm, C., Helv. Chim. Acta, 41, 297, 1762 (1958).
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NAWA, H., UCHIBAYASHI, M., KAMIYA, T. et al. Microbiological Transformation of a Cardiac Aglycone. Nature 184, 469–470 (1959). https://doi.org/10.1038/184469a0
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DOI: https://doi.org/10.1038/184469a0
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