Uræmia and its Treatment by Arginase Inhibitor

Abstract

URÆMIA is retention of urea in the body, and is due to renal insufficiency. It has been proved beyond doubt that the kidney is the only organ through which urea can be eliminated from the body¹. Therefore renal insufficiency of an organic or a functional type will reverse the clearance of urea from the body, with consequent retention. The methods involving intestinal and peritoneal dialysis, artificial kidney and possibilities of a successful kidney homotransplant for the treatment of uræmia are mainly based on the principle of eliminating urea from the body. The problem becomes very much simplified if technique can be evolved checking the synthesis of urea, which obviously could cause least damage to the patient.