Abstract
During the past several months we have been studying the serological behaviour of various Asian influenza strains, with particular reference to their sensitivity to non-specific serum hæmagglutination inhibition (HI). Of the five strains studied, four were highly sensitive, one moderately so, to human serum inhibitor in early egg passages. Sensitivity was lost abruptly on continued passage in the allantoic cavity in four of the strains. More detailed studies on one of the strains, A/Roberge, have shown that loss of sensitivity to inhibition of hæmagglutination is correlated with (a) resistance in ovo to the neutrallizing activity of normal horse serum and (b) increased enzymatic activity as measured by rapidity of elution from chicken red blood cells.
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References
Cohen, A., and Belyavin, G., Virology, 7, 59 (1959).
Hirst, G. K., J. Exp. Med., 76, 195 (1942).
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JAMES, S., FISET, P. Serum Inhibitors of Asaian Strains of Influenza Virus. Nature 184, 1656–1657 (1959). https://doi.org/10.1038/1841656a0
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DOI: https://doi.org/10.1038/1841656a0
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