Abstract
FROM the observation that the nitrogen-15 of labelled ammonium citrate administered to rats appears in the 6–NH2 group of the muscle adenine nucleotides, Kalckar and Rittenberg1 have concluded that the nucleotides take part in very rapid reversible de-animation reactions. That ammonium citrate nitrogen is similarly incorporated into rabbit skeletal muscle has been confirmed by Newton and Perry2. They have further demonstrated that aspartic acid is a more active donor of the 6–NH2 group and that the enzymic activity is concentrated in the sarcoplasmic fraction of muscle.
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References
Kalckar, H. M., and Rittenberg, D., J. Biol. Chem., 170, 455 (1947).
Newton, A. A., and Perry, S. V., Nature, 179, 50 (1957).
Bendall, J. R., and Davey, C. L., Biochim. Biophys. Acta, 26, 93 (1957).
Nekhorocheff, J., and Wajzer, J., Arch. Sci. Physiol., 6, 275 (1952).
Lieberman, I., J. Biol. Chem., 228, 327 (1956).
Parnas, J. K., Lewinski, W., Jaworska, J., and Umschweif, B., Biochem. Z., 228, 366 (1930).
Kalckar, H. M., J. Biol. Chem., 167, 466 (1947).
Perry, S. V., Physiol. Rev., 36, 1 (1956).
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DAVEY, C. Synthesis of Adenylosuccinic Acid in Preparations of Mammalian Skeletal Muscle. Nature 183, 995–996 (1959). https://doi.org/10.1038/183995a0
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DOI: https://doi.org/10.1038/183995a0
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