Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Synthesis of Dextran Sulphate labelled with Carbon-14 and Tracer Experiments in the Rat

Abstract

PREVIOUS experiments1,2 with the heparinoid anticoagulant, dextran sulphate, in experimental animals and man have established that between 40 and 50 per cent of a single intravenous dose of dextran sulphate of a molecular size suitable for clinical use was excreted in the urine in 48 hr.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jeavons, S. M., Walton, K. W., and Ricketts, C. R., Brit. Med. J., ii, 1016 (1956).

  2. Ricketts, C. R., Walton, K. W., and Saddington, S. M., Biochem. J., 58, 532 (1954).

    Article  CAS  Google Scholar 

  3. Odeblad, E., and Boström, H., Acta Path. Microbiol. Scand., 31, 339 (1952).

    Article  CAS  Google Scholar 

  4. Ricketts, C. R., Biochem. J., 51, 129 (1952).

    Article  CAS  Google Scholar 

  5. Frazer, A. C., Pover, W. F. R., and Sammons, H. G., Atomic Energy Research Estab., Harwell, Proc. Second Radio-isotope Conference, Oxford, 1, 298 (Butterworths, London, 1954).

    Google Scholar 

  6. Walton, K. W., Brit. J. Pharmacol., 9, 1 (1954).

    CAS  PubMed  Google Scholar 

  7. Skipper, H. E., Bryan, C. E., White, L., and Hutchison, O. S., J. Biol. Chem., 173, 371 (1948).

    CAS  PubMed  Google Scholar 

  8. Calvin, M., Heidelberger, C., Reid, J. C., Tolbert, B. M., and Yank-wich, P. F., in “Isotopic Carbon” (Wiley, New York, 1949).

    Google Scholar 

  9. Henriques, F. C., Kistiakowsky, G. B., Marguetti, C., and Schneider, W. G., Indust. Eng. Chem., Anal., 18, 349 (1946).

    Article  CAS  Google Scholar 

  10. Donaldson, H. H., “The Rat: Data and Reference Tables for the Albino Bat and the Norway Bat”, second edit. Memoirs of the Wistar Institute of Anatomy and Biology, No. 6 (Philadelphia, 1924).

    Google Scholar 

  11. Lathrop, K. A., and Allen, J. G., quoted by Gropper, A. L., Raisz, L. G., and Amspacher, W. H., Sura. Gynec. Obstet., 95, 521 (1952).

    Google Scholar 

  12. Morrow, P. E., Hodge, H. C., Neumann, W. F., Maynard, E. A., Blanchet, H. K., Fasset, D. W., and Birk, R. E., J, Pharmacol., 105 (1952).

  13. Husemann, E., Hoffmann, E. G., Lotterle, R., and Widersheim, M., Experientia, 8, 153 (1952).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WEIGEL, H., WALTON, K. Synthesis of Dextran Sulphate labelled with Carbon-14 and Tracer Experiments in the Rat. Nature 183, 981–982 (1959). https://doi.org/10.1038/183981a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/183981a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing