Abstract
IT is a well-established fact that under stress conditions the organism calls for increased cortico-steroid activity1. The response to such a call has been believed to occur solely by an increased cortico-steroid production, that is, by increased pituitary-adrenocortical activity. Recent studies2,3 have brought to light certain facts which suggest that the organism possesses an additional mechanism to meet the increased demand for corticosteroid activity. This mechanism functions by increasing the sensitivity of the target organs to corticosteroids.
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References
Selye, H., “The Physiology and Pathology of Exposure to Stress” (Acta, Inc. Med. Pub., Montreal, 1950).
Kramár, J., Levine, V. E., Meyers, V. W., and Sass, R. N., Amer. J. Physiol., 192, 603 (1958).
Kramár, J., Simay-Kramár, M., and Carnazzo, A. J., J. App. Physiol., 13, 257 (1958).
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KRAMÁR, J., McCARTHY, H., SIMAY-KRAMÁR, M. et al. Target Organ Activation by Stress. Nature 183, 1522–1523 (1959). https://doi.org/10.1038/1831522a0
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DOI: https://doi.org/10.1038/1831522a0
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