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Neuronal Dye-Sorption as a Histochemical Indicator of Nervous Activity

Abstract

PROTEIN extracts from electrically stimulated nervous tissue have been reported to undergo changes resembling those of reversible denaturation1. Denaturation of protein, however, enhances dye-protein interaction2. It was postulated, therefore, that excitation of nervous tissue could be demonstrated histochemically3.

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References

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  3. Fischer, R., paper presented at the meeting of the Ohio Valley Section of the Soc. Bxp. Biol. Med., Columbus, Ohio, Nov. 1, 1958 (in the press).

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FISCHER, R., ZEMAN, W. Neuronal Dye-Sorption as a Histochemical Indicator of Nervous Activity. Nature 183, 1337–1338 (1959). https://doi.org/10.1038/1831337a0

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