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Comparative Kinetic Behaviour of Thrombin, Plasmin and Trypsin toward Synthetic Substrates

Nature volume 182, pages 461–462 (1958)Cite this article

Abstract

THROMBIN preparations catalyse the hydrolysis of synthetic arginyl1 and lysyl2 substrates. While plasmin and trypsin may appear as contaminants in thrombin preparations, we present here kinetic data for the action of these three enzymes toward p-toluenesulphonyl-L-arginine methyl ester (I) and the methyl and ethyl esters of lysine which rule out plasmin or trypsin impurities as the origin of the lysyl esterase activity of thrombin.

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Authors and Affiliations

  1. Department of Chemistry, Cornell University, Ithaca, New York

    H. A. SCHERAGA, S. EHRENPREIS & E. SULLIVAN

Authors
  1. H. A. SCHERAGA
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  2. S. EHRENPREIS
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  3. E. SULLIVAN
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SCHERAGA, H., EHRENPREIS, S. & SULLIVAN, E. Comparative Kinetic Behaviour of Thrombin, Plasmin and Trypsin toward Synthetic Substrates. Nature 182, 461–462 (1958). https://doi.org/10.1038/182461a0

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