Abstract
The paper of mine referred to pointed out that it was not yet possible to say whether the two effects discussed would account for the whole of the differences between the slopes of probit–log-dose lines for houseflies resistant and susceptible to DDT. Additional genetic heterogeneity in strains of resistant flies could, it seems, operate side by side with the other two effects in reducing the slopes of the lines ; it might also intensify the second of the other two effects. When applied to resistant flies with DDT, bis(p-chlorophenyl) methyl carbinol synergizes the action of the DDT by depressing its enzymatic detoxification1,2, and at the same time increases the slope of the line relating probit mortality to the log-dose of DDT2 ; this strongly suggests that the detoxification mechanism is directly concerned in depressing the slope of the line for DDT without synergist, as discussed in my paper.
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References
Moorefield, H. H., and Kearns, C. W., J. Econ. Ent., 48, 403 (1955).
Perry, A. S., Mattson, A. M., and Buckner, A. J., Biol. Bull., Woods Hole, 104, 426 (1953).
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HEWLETT, P. Dosage–Mortality Curves for Houseflies Susceptible and Resistant to DDT. Nature 182, 404 (1958). https://doi.org/10.1038/182404a0
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DOI: https://doi.org/10.1038/182404a0
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