Abstract
A NUMBER of workers have investigated, in experimental animals, the effects of tranquillizing drugs on learned behaviour motivated by fear. John et al.1 have suggested that reserpine inhibits conditioned avoidance behaviour by interference with learned associations, whereas Weiskrantz2 believes that reserpine reduces sensory perception. Miller3 suggested that chlorpromazine reduces fear motivation and that this is independent of its sedative action or of an effect on motor co-ordination.
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References
John, E. R., Wenzel, B. M., and Tschirgi, R. D., Science, 127, 25 (1958).
Weiskrantz, L., in “Psychotropic Drugs”, edit. by Garattini, S., and Ghetti, V., 67 (Elsevier, 1957).
Miller, R. E., Murphy, J. V., and Mirsky, I. A., J. Pharmacol., 120, 379 (1957).
Broadhurst, P. L., Brit. J. Psychol., 48, 1 (1957).
Hunt, H. F., and Otis, L. S., J. Comp. Physiol. Psychol., 46, 378 (1953).
Hunt, H. F., Ann. N.Y. Acad. Sci., 65, 258 (1956).
Hall, C. S., J. Comp. Psychol., 18, 385 (1934).
Jacobsen, E., in “Psychotropic Drugs”, edit. by Garattini, S., and Ghetti, V., 119 (Elsevier, 1957).
Larsen, V., Acta Pharmacol. et Toxicol, 11, 405 (1955).
Courvoisier, S., Ducrot, R., Fournel, J., and Julou, L., C.R. Soc. Biol., 151, 1144 (1957).
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RYALL, R. Effect of Drugs on Emotional Behaviour in Rats. Nature 182, 1606–1607 (1958). https://doi.org/10.1038/1821606a0
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DOI: https://doi.org/10.1038/1821606a0
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