Abstract
DURING the course of investigation of the reasons underlying the ability of cartilage grafts to survive in foreign hosts for long periods, the effects of cartilage homografts and heterografts on the regional lymph node were studied in order to determine whether such grafts were antigenic1. The results of this test indicated that both types of graft do evoke an active immune response in the host animal, and it was discovered, further, that heterografts do so even after having been boiled for periods of up to 10 min.2. This test does not, however, indicate whether the host animal becomes fully immunized by the foreign cartilage, and in order to determine whether this is so, rabbits bearing cartilage homografts have been challenged with skin homografts from the cartilage donor.
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CRAIGMYLE, M. Antigenicity and Survival of Cartilage Homografts. Nature 182, 1248 (1958). https://doi.org/10.1038/1821248a0
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DOI: https://doi.org/10.1038/1821248a0
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