Abstract
ADMINISTRATION of large doses of 5-hydroxy-tryptophan (60–100 mgm./kgm.) to rabbits produces marked central effects, for example, mydriasis, hyperpnœa, tachycardia, tremor and ataxia1,2. These effects seemed to be similar to those observed after giving lysergic acid diethylamide1. As lysergic acid diethylamide very markedly raises the blood-sugar level in the rabbit by a central action3,4, 5-hydroxy-tryptophan should also produce hyperglycæmia if its central effect is similar to that of lysergic acid diethylamide.
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References
Udenfriend, S., Weissbach, H., and Bogdanski, D. F., J. Biol. Chem., 224, 803 (1957).
Costa, E., Rinaldi, F., and Himwich, H. E., in “Psychotropic Drugs” 21 (Elsevier, 1957).
Rothlin, E., Cerletti, A., Konzett, H., Schalch, W. R., and Taeschler, M., Experientia, 12, 154 (1956).
Konzett, H., Abstracts of Communications, XX Internat. Physiol. Congress, 518 (1956).
Shaffer, P. A., and Hartmann, A. F., J. Biol. Chem., 45, 365 (1921).
Horita, A., and Gogerty, J. H., J. Pharm. Exp. Therap., 122, 195 (1958).
Sirek, A., Nature, 179, 376 (1957).
West, G. B., Nature, 182, 182 (1958).
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KONZETT, H. Hyperglycæmia induced in Rabbits by 5-Hydroxytryptophan. Nature 182, 1168–1169 (1958). https://doi.org/10.1038/1821168a0
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DOI: https://doi.org/10.1038/1821168a0
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