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3-Ethoxy-4-hydroxybenzoic Acid in Human Urine

Abstract

IN a recent communication1 an increased excretion of vanillic acid during the stress of motor-rally driving was reported. The 1958 Royal Automobile Club rally offered an opportunity to confirm this finding, and three samples of urine were collected from each of two subjects during the third and fourth days. This was after a considerably longer period of stress than had been experienced in the previous experiment and was determined by the accessibility of the subjects. Acid-hydrolysed urines were examined by the method used previously2 and both hydrolysed and unhydrolysed urines by a modification of the method of Armstrong et al.3. In all the samples, vanillic acid was detected only in perfectly normal amount.

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References

  1. Smith, P., and Bennett, A. M. H., Nature, 181, 709 (1958).

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  2. Smith, P., Chem. and Indust., 758 (1958).

  3. Armstrong, M. D., Shaw, K. N. F., and Wall, P. E., J. Biol. Chem., 218, 293 (1956).

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HILL, G., RATCLIFFE, J. & SMITH, P. 3-Ethoxy-4-hydroxybenzoic Acid in Human Urine. Nature 182, 1160–1161 (1958). https://doi.org/10.1038/1821160a0

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