Abstract
THE in vivo metabolism of œstradiol-17β leads to the formation of ring D ketols with a hydroxyl group at C16. These compounds are of interest because they may be either intermediates in the further transformation of œstrone or end products formed from the oxidation of ring D glycols. 16α-Hydroxyœstrone has been isolated from the urine of pregnant women by Marrian, Watson and Panattoni1. This communication reports the identification of the recently synthesized 16β-hydroxyœstrone2 as a metabolite of œstradiol-17β in man. The product is formally related to the œstrogen metabolite Δ1,3,5(10) œstratriene-3,16β,17β-triol3.
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References
Marrian, G. F., Watson, E. J. D., and Panattoni, M., Biochem. J., 65, 12 (1957).
Biggerstaff, W. R., and Gallagher, T. F., J. Org. Chem., 22, 1220 (1957).
Marrian, G. F., and Bauld, W. S., Biochem. J., 59, 136 (1955).
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BROWN, B., FISHMAN, J. & GALLAGHER, T. 16β-Hydroxyœstrone, a Metabolite of Œstradiol in Man. Nature 182, 50–51 (1958). https://doi.org/10.1038/182050b0
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DOI: https://doi.org/10.1038/182050b0
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