Abstract
THE ability of morphine to inhibit certain pituitary functions has been established. The administration of morphine on the day of pro-œstrus resulted in the suppression of ovulation1. It is also possible by pre-treatment with morphine to prevent the secretion of adrenocorticotrophic hormone which follows an injection of adrenaline or other stress2. Sawyer et al. 3 have observed that morphine in doses sufficient to block the activation of the pituitary depressed the electrical activity of the central nervous system and also of the hypothalamic centres. The present experiment was designed to ascertain whether morphine is capable of blocking the secretion of the thyroid-stimulating hormone of the pituitary also.
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References
Barraclough, C. A., and Sawyer, C. H., Endocrinol., 57, 329 (1955).
Briggs, F. N., and Munson, P. L., J. Clin. Endocrinol., 14, 811 (1954).
Sawyer, C. H., Critchlow, B. V., and Barraclough, C. A., Endocrinol., 57, 343 (1955).
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SÁMEL, M. Blocking Effect of Morphine on the Secretion of Thyroid-stimulating Hormone in Rats. Nature 181, 845–846 (1958). https://doi.org/10.1038/181845a0
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DOI: https://doi.org/10.1038/181845a0
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