Abstract
RECENTLY, it has been reported by several investigators that there exist cis- and trans-isomers in 2 : 4-dinitrophenylhydrazones of pyruvic acid1 2, benzoylformic acid3 and α-keto-β,β-dimethyl-γ-buty-rolactone4 as shown in (I) and (II) respectively. This was supported by infra-red spectra, since the wave-numbers of the stretching bands of CO and NH of the cis-form were smaller than those of the trans-form. Our interest in the structures of the isomers of these hydrazones has led us to the discovery of a new chelating reaction, capable of differentiating the two forms.
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References
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KATSUKI, H., SUMIZU, K., MORIWAKI, T. et al. A New Reaction for the Differentiation of cis- and trans-Isomers of Nitrophenyl-hydrazones of some α-Keto Acids. Nature 181, 639 (1958). https://doi.org/10.1038/181639a0
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DOI: https://doi.org/10.1038/181639a0
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