Abstract
THE accepted criterion of response in the intra-vaginal Allen–Doisy assay is cornification of the vaginal epithelium, which occurs 48–54 hr. after administration of an effective dose of œstrogen1,2. Cornification is the end-point of a lengthy chain of events involving cell multiplication and growth of the epithelium.
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References
Allen, E., and Doisy, E. A., Physiol. Rev., 7, 600 (1927).
Emmens, C. W., “Hormone Assay”, Chap. 13 (Academic Press, New York, 1950).
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MARTIN, L., CLARINGBOLD, P. A Highly Sensitive Assay for Œstrogens. Nature 181, 620–621 (1958). https://doi.org/10.1038/181620b0
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DOI: https://doi.org/10.1038/181620b0
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