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Relationship between Chlorpromazine and Anoxia

Nature volume 181, pages 1341–1342 (1958)Cite this article

An Erratum to this article was published on 31 May 1958

Abstract

THE effects of chlorpromazine on metabolism have been studied thoroughly. The results of Laborit1, Benite2 and others show that it has a depressing influence. It was also suggested that chlorpromazine would influence anoxia produced by low oxygen pressure. This question was answered by Cheymol and Levasort3, and by Rejsic4 and Ankermann5. The results describe a lowered resistance to anoxia produced by chlorpromazine. Bean6 produced a lowered resistance in Sprague–Dawley rats by administering chlorpromazine while they were exposed to an oxygen pressure of several atmospheres. We know that after a short exposure to oxygen at low pressures an induced polycythæmia occurs in some experimental animals, for example, rats and rabbits. This polycythæmia represents one of the adaptation reactions to anoxia. We have investigated the influence of chlorpromazine on this induced polycythæmia.

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References

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Authors and Affiliations

  1. Department of Physiology, Charles University, Pilsen, Czechoslovakia

    V. LINDAUR

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  1. V. LINDAUR
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LINDAUR, V. Relationship between Chlorpromazine and Anoxia. Nature 181, 1341–1342 (1958). https://doi.org/10.1038/1811341a0

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  • DOI: https://doi.org/10.1038/1811341a0

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