Abstract
SEVERAL papers1,2 have been published on the separation of strychnine and brucine by paper chromatography, but none of these gives a satisfactory separation of these alkaloids, particularly in regard to the quantitative determination of strychnine after its elution from the chromatogram. The difference between the R F values of strychnine and brucine is only 0.15–0.18 even under the optimum conditions.
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References
Munier, R., and Macheboeuf, M., Bull. Soc. Chim. Biol., 32, 210 (1950); 33, 854 (1951).
Gore, D., and Adshead, J. M., J. Pharm. Pharmacol., 4, 803 (1952).
Dušinský, G., Acta Chimica Hung. (in the press).
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DUŠINSKÝ, G., TYLLOVÁ, M. A New Method for separating Strychnine and Brucine by Paper Chromatography. Nature 181, 1335–1336 (1958). https://doi.org/10.1038/1811335a0
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DOI: https://doi.org/10.1038/1811335a0
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