Abstract
IT has been shown by Frappier and Guérault1,2, and Frappier, Guérault and De Repentigny3, that the antigen of Haemophilus pertussis which protects mice against intracerebral infection could be washed off the bacteria by saline (0.85 per cent sodium chloride). As this protective effect in the mouse is accepted as an indicator of the efficiency of vaccines in protecting children against whooping-cough it would appear that saline washings afford a ready means of obtaining the immunizing antigen of the organism free from the bulk of the bacterial cell. The washings were obtained from bacteria grown in a fluid medium, they were practically devoid of toxicity and stimulated agglutinin production in rabbits.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Frappier, A., and Guérault, A., Rev. Canad. Biol., 13, 416 (1954).
Frappier, A., and Guérault, A., Rev. Canad. Biol., 14, 193 (1955).
Frappier, A., Guérault, A., and De Repentigny, J. C. R., 7th Internat. Congress Comparative Path., Lausanne, 2, 142 (1955).
De Repentigny, J., and Frappier, A., Can. J. Microbiol., 2, 677 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GUÉRAULT, A., MAITLAND, H. Surface Antigens of Haemophilus pertussis . Nature 181, 122–123 (1958). https://doi.org/10.1038/181122b0
Issue Date:
DOI: https://doi.org/10.1038/181122b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.