Abstract
MANY consider that the blood clotting defect in hæmophilia and Christmas disease is due to a deficiency of one of the blood clotting factors, namely, antihæmophilic globulin1 or Christmas factor (plasma thromboplastin component)2. Others believe that the anomaly is produced by a derangement in the balance between a lipid inhibitor and a platelet plasma co-factor3.
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References
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NOUR-ELDIN, F., WILKINSON, J. A Hitherto Unknown Blood Clotting Defect in Hæmophilia and Christmas Disease. Nature 180, 990–991 (1957). https://doi.org/10.1038/180990b0
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DOI: https://doi.org/10.1038/180990b0
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