Abstract
THE administration of glucose, mannose or fructose, but not galactose or several other sugars tested, can prevent the effect of a normally diabetogenic dose of alloxan. This protection was found by Bhattacharya1,2 in the rat. From the relative efficiencies of these sugars he concluded that the diabetogenic action of alloxan could depend on an inactivation of the hexokinase of the beta cells of the pancreas. Arteta and co-workers have confirmed the protective effect of glucose in the dog3. They have also observed that insulin3 and floridzin4 can increase, and adrenalin5 and glucagon6 can decrease, the sensitivity towards alloxan, apparently in relation to their effect on the blood sugar-level. The work described here on the effect of alloxan on pancreas hexokinase in vitro does not support the hexokinase inhibition theory of alloxan action.
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References
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VILLAR-PALASI, C., CARBALLIDO, A., SOLS, A. et al. Sensitivity of Pancreas Hexokinase towards Alloxan and its Modification by Glucose. Nature 180, 387–388 (1957). https://doi.org/10.1038/180387b0
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DOI: https://doi.org/10.1038/180387b0
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