Abstract
RECENTLY1, we compared oxytocin blood-levels in women during non-pregnancy, pregnancy, labour and lactation under similar conditions of blood collection, extraction and assay, using the sensitized virgin rat uterus. Similar experiments were performed on lactating cows and goats (Hawker, R. W., and Roberts, V. S., unpublished work) and on women who failed to lactate after parturition (Hawker, R. W., unpublished work). The test applied to the extract activity to identify it with oxytocin was its destruction by 0.01 M thioglycollate3. However, substantial activity frequently remained after thioglycollate treatment; and so it was concluded that another oxytocic substance was often present in blood. Some initial experiments regarding the origin of this have been made.
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References
Hawker, R. W., and Robertson, P. A., J. Clin. Endocrinol. Metab., 17, 448 (1957); Endocrinol., 60, 652 (1957).
Bisset, G. W., and Walker, J. M., J. Physiol., 126, 588 (1954).
Van Dyke, H. B., Chow, B. F., Greep, R. O., and Rothen, A., J. Pharmacol. Exp. Therap., 74 190 (1942).
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ROBERTSON, P., HAWKER, R. A Second Oxytocin in the Hypothalamus. Nature 180, 343–344 (1957). https://doi.org/10.1038/180343a0
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DOI: https://doi.org/10.1038/180343a0
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