Abstract
BECAUSE of the recent interest in the mechanism of action of the two antidiabetic sulphonylurea derivatives, carbutamide (N1 sulphanilyl N2 n-butylcarbamide) and tolbutamide (N1 p-toluylsulphonyl N2 n-butylcarbamide), the effect of these compounds on the liver transaminase system was investigated, since inhibition of transamination reactions could lead to a decrease in the rate of neoglucogenesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cammaratta, P. S., and Cohen, P. P., J. Biol. Chem., 187, 439 (1950).
Gale, E. F., Biochem. J., 39, 46 (1945).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BORNSTEIN, J. Inhibition of Alanine Transaminase by the Hypoglycæmic Sulphonylurea Derivatives. Nature 179, 534–535 (1957). https://doi.org/10.1038/179534a0
Issue Date:
DOI: https://doi.org/10.1038/179534a0
This article is cited by
-
Tierexperimentelle Thioacetamid-Leberschäden unter therapeutischen Sulfonylharnstoffgaben (D 860)
Zeitschrift für Die Gesamte Experimentelle Medizin (1958)
-
�ber die Blutzuckersenkung durch N-[4-Amino-benzolsulfonyl]-N?-n-butyl-harnstoff und N-[4-Methyl-benzolsulfonyl]-N?-n-butyl-harnstoff nach Leberausschaltung
Die Naturwissenschaften (1958)
-
Reversibilit�t von pathologischen Serum-Labilit�tsproben, Elektrophoresediagramm und Leberfunktionstests bei chronischen Lebererkrankungen (chronische Hepatitis, Lebercirrhosen) unter Sulfonylharnstoffgaben (D 860)
Klinische Wochenschrift (1957)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.