Abstract
IT is well known that skeletal muscle extracts rapidly convert adenine micleotides to inosine monophosphate; yet although the latter and other inosine nucleotides have been detected in muscle, the significance of these substances and their relation to metabolic and physiological activity have been matters for controversy1,2. Parnas considered that reamination of inosine monophosphate was an oxidative process, as did Engelhardt3 in his postulated adenylic cycle, whereas Nekhorocheff and Wajzer4 have recently provided evidence that creatine can act as a precursor of the 6-NH2 group of the adenine nucleotides.
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References
Parnas, J.-K., C.R. Soc. Biol., 101, 37 (1929).
Embden, G., Carstensen, M., and Schumacher, M., Z. physiol. Chem., 179, 186 (1928).
Engelhardt, V. A., Special Lecture, 2nd Int. Congr. Biochem., Paris, 1952.
Nekhorocheff, J., and Wajzer, J., Arch. Sci. Physiol., 6, 275 (1952). Nekhorocheff, J., Proc. 3rd Int. Congr. Biochem. Brussels, 1955 p. 84.
Kalckar, H. M., and Rittenberg, D., J. Biol. Chem., 170, 455 (1947).
Carter, C. E., and Cohen, L. H., J. Amer. Chem. Soc., 77, 499 (1955).
Abrams, R., and Bentley, M., J. Amer. Chem. Soc., 77, 4179 (1955). Liebermann, I., ibid., 78, 251 (1956).
Kometiani, P. A., and Klein, E. E., Biochimia, 21, 389 (1956).
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NEWTON, A., PERRY, S. Incorporation of Nitrogen-15 in the 6-NH2 Group of Adenosine Triphosphate by Muscle Extracts. Nature 179, 49–50 (1957). https://doi.org/10.1038/179049a0
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DOI: https://doi.org/10.1038/179049a0
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