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Factors favouring Restriction to 1,2 Glycols of Materials coloured by the Periodic Acid–Schiff Reaction

Nature volume 178, pages 914–915 (1956)Cite this article

Abstract

WHILE periodate oxidation was reported first as a histological method for the demonstration of mucin1, subsequent studies showed its utility for the colouring of glycogen2 and other carbohydrates or carbohydrate containing materials3 in tissue sections. In its present histochemical use, periodate oxidation of tissue sections produces aldehyde presumably from certain specific linkages, chiefly 1,2 glycols and amino, alkyl-amino or ketone substituents of 1,2 glycols. The aldehydes produced by periodate oxidation are coloured with Schiff's reagent.

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Authors and Affiliations

  1. Department of Pathology, University of Alabama Medical Center, Birmingham, 3, Alabama

    J. F. A. McMANUS

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  1. J. F. A. McMANUS
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McMANUS, J. Factors favouring Restriction to 1,2 Glycols of Materials coloured by the Periodic Acid–Schiff Reaction. Nature 178, 914–915 (1956). https://doi.org/10.1038/178914a0

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