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Pharmacological Effects of Certain Diaminodiphenoxy Alkanes

Nature volume 178, pages 806–807 (1956)Cite this article

Abstract

A SERIES of diaminodiphenoxy alkanes was found independently by Raison and Standen1 and Collins, Davies and Hill2 to possess high schistosomicidal activity. Hill3 has described in detail the therapeutic effects of one of these compounds in comparison with lucanthone (Miracil D), which is used in the treatment of bilharzia, and found that in mice the compound 1: 5-di (P-aminophenoxy) pentane dihydrochloride (M. and B. 968A) was more active than lucanthone. The relative therapeutic indices were 3.3 (LD50= 0.62 mgm./gm., CD50 = 0.19 mgm./gm.) and 0.9, respectively, and it had a more rapid action in clearing the mice of the schistosomes.

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References

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Authors and Affiliations

  1. May and Baker, Ltd., Dagenham, Essex

    N. D. EDGE, D. F. J. MASON & R. WIEN

  2. Institute of Ophthalmology, London

    N. ASHTON

Authors
  1. N. D. EDGE
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  2. D. F. J. MASON
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  3. R. WIEN
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  4. N. ASHTON
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EDGE, N., MASON, D., WIEN, R. et al. Pharmacological Effects of Certain Diaminodiphenoxy Alkanes. Nature 178, 806–807 (1956). https://doi.org/10.1038/178806a0

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