Abstract
DIAMINO-DIPHENYL-SULPHONE and a number of its derivatives have been found to be very effective in the treatment of leprosy ; but the exact mode of their action on the affected tissue and invading Mycobacterium has not yet been definitely established1–3. In the present work, diamino-diphenyl-sulphone labelled with sulphur-35 was used for studying the time variation of concentration of the drug in blood and healthy and diseased skin tissues of the leprosy patients. An interesting observation was that the drug was found to be localized to a greater extent in the affected tissues compared to healthy ones. Such studies were not possible with the help of earlier colorimetric techniques4, as these required tissues in bulk. The method used here was found to be ten times more sensitive than the colorimetric techniques.
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References
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CHATTERJEE, K., PODDAR, R. Preferential Uptake of Sulphone by Affected Skin Tissue of Leprosy Patients as detected by a Tracer Method. Nature 178, 799–800 (1956). https://doi.org/10.1038/178799b0
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DOI: https://doi.org/10.1038/178799b0
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