Abstract
IT has already been shown by Slopek and one of us (T. U.) that 1,3-oxazine derivatives have a marked antituberculous activity in vivo. However, those compounds which are derivatives of nitroparaffins and contain a nitro-group show a relatively high toxicity on prolonged administration. This led one of us (T. U.) to look for less toxic derivatives of 1,3-oxazine2.
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References
Urbański, T., and Slopek, S., Nature, 168, 562 (1951).
Urbański, T., and Gac-Chylińska, B., Roczniki Chem., 30, 185, 195 (1956).
Burke, W. J., J. Amer. Chem. Soc., 71, 609 (1949); 74, 3601 (1952); 76, 1291, 1677 (1954). Mizuch, K. G., J. Gen. Chem. (U.S.S.R.), 23, 861 (1953).
Urbański, T., Gürne, D., Eckstein, Z., and Slopek, S., Bull. Acad. Pol. Sci., Cl. III, 3, 397 (1955).
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URBAŃSKI, T., RADZIKOWSKI, C., LEDÓCHOWSKI, Z. et al. Biological Activity of Benzoxazine-1,3 Derivatives, particularly against Experimental Sarcoma. Nature 178, 1351–1352 (1956). https://doi.org/10.1038/1781351a0
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DOI: https://doi.org/10.1038/1781351a0
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