Abstract
IT has been shown that the sensory input into the central nervous system can be modulated at the very origin of the nervous message—at the receptor1. For example, the response of a cutaneous touch receptor to a constant mechanical stimulus may be increased by excitation of the sympathetic nerve supply to the frog's skin. Only a few sympathetic impulses—in some cases only one—are required to modulate the activity of the receptor. The effect appears to be due to the release of an adrenaline-like substance by sympathetic fibres ending near the tactile receptor1. The present communication deals with the facilitatory action of sympathetic amines on an isolated mechano-receptive sense organ.
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References
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LOEWENSTEIN, W., ALTAMIRANO-ORREGO, R. Enhancement of Activity in a Pacinian Corpuscle by Sympathomimetic Agents. Nature 178, 1292–1293 (1956). https://doi.org/10.1038/1781292a0
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DOI: https://doi.org/10.1038/1781292a0
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