Abstract
IT is well known that many diseases produce a marked alteration in the level of the total serum protein. Furthermore, it has been shown by electrophoretic analysis that certain diseases bring about distinctive changes in the relative concentrations of the different serum proteins. In early active tuberculosis1 there is a rise in the γ-globulin fraction of the serum protein and a corresponding fall in the albuminlevel. As the disease progresses the α2-globulin concentration also increases and in advanced tuberculosis all the globulin concentrations are raised. In contrast, patients with nephrosis2 show an increase in the α2-globulin concentration which is usually associated with a decrease in the γ-globulin fraction.
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SNELL, R., GROSS, W. Electrophoretic Evaluation of the Serum Proteins in Malignant Disease. Nature 178, 1238 (1956). https://doi.org/10.1038/1781238a0
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DOI: https://doi.org/10.1038/1781238a0
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