Abstract
IT is well known that protein deficiency causes considerable interference with endochondral calcification in growing rats, the growth of the epiphyseal plate and the formation of calcified trabeculæ ceasing, the face of the plate being finally sealed off with bone1,2. Similar changes are seen after hypophysectomy3. In the case of the continually erupting incisor tooth of the rat, protein or amino-acid deficiency causes very slight changes, chiefly an interference with the calcification of the dentin4–6. Hypophysectomy induces very marked changes in the incisor, the chief defect being caused by the processes of eruption and incremental growth being differently affected. As a result, there is a relative overgrowth of dentin, the pulp cavity becomes smaller and later the formative end of the tooth is thrown into folds. Other degenerative changes also occur7,8.
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IRVING, J. Action of the Hypophysis and of Dietary Protein on the Calcifying Tissues. Nature 178, 1231 (1956). https://doi.org/10.1038/1781231a0
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DOI: https://doi.org/10.1038/1781231a0
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