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Biochemical Tests for Malignancy applied to a New Strain of Human Cells

Nature volume 178, pages 1179–1180 (1956)Cite this article

Abstract

TRANSFORMATIONS of normal cells of rats and mice into malignant strains have been reported to occur under tissue culture conditions on a few occasions1, and in such cases it was possible to demonstrate their malignancy by inoculation into the appropriate animal strains. During tissue-culture experiments with human cells, an abnormal strain appeared in roller-tubes of liver cells from a 20-week embryo. The new strain showed some of the characteristics of malignant cells, and we had to rely on biochemical tests to obtain further evidence of their malignancy.

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References

  1. Goldblatt, H., and Cameron, G., J. Exp. Med., 97, 525 (1953). Sanford, K. K., Likely, G. D., and Earle, W. R., J. Nat. Cancer Inst., 15, 215 (1954).

    Article  CAS  Google Scholar 

  2. Healy, G. M., Fisher, D. C., and Parker, R. C., Proc. Soc. Exp. Biol. Med., 89, 71 (1955).

    Article  CAS  Google Scholar 

  3. Vendrely, R., “The Nucleic Acids” (ed. Chargaff, E., and Davidson. J. N.), 2, Chap. 19 (Academic Press, 1955).

    Google Scholar 

  4. Mellors, R. C., Cancer Res., 15, 557 (1955).

    CAS  PubMed  Google Scholar 

  5. Weinhouse, S., “Adv. Cancer Res.”, 3, 269 (1955).

    Article  CAS  Google Scholar 

  6. Warburg, O., Science, 123, 309 (1956).

    Article  ADS  CAS  Google Scholar 

  7. Woods, M. W., Wight, K., Hunter, J., and Burk, D., Biochim. Biophys. Acta, 12, 329 (1953).

    Article  CAS  Google Scholar 

  8. Beck, W. S., and Valentine, W. N., Cancer Res., 13, 309 (1953).

    CAS  PubMed  Google Scholar 

  9. Moore, A. E., Southam, C. M., and Sternberg, S. S., Science, 124, 127 (1956).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Biochemistry Department, The Queen's University, Belfast

    I. LESLIE, W. C. FULTON & R. SINCLAIR

Authors
  1. I. LESLIE
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  2. W. C. FULTON
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  3. R. SINCLAIR
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LESLIE, I., FULTON, W. & SINCLAIR, R. Biochemical Tests for Malignancy applied to a New Strain of Human Cells. Nature 178, 1179–1180 (1956). https://doi.org/10.1038/1781179a0

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