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Influence of Atropine and Morphine on the Liberation of Acetylcholine from the Guinea Pig's Intestine

Nature volume 178, pages 1121–1122 (1956)Cite this article

Abstract

IT has been shown by Chujyo1 that distension of the lumen of the guinea pig's intestine results in ar increased output of acetylcholine. Distension of the lumen also leads to a contraction of the longitudinal muscle, which is probably brought about by the acetylcholine released. Atropine and morphine abolish this contraction; but the mechanism of the action of these two drugs appears to be different. The following experiments show that whereas atropine apparently acts by preventing the action of the released acetylcholine on the longitudinal muscle, morphine inhibits the release of acetylcholine.

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References

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität, Frankfurt am Main

    W. SCHAUMANN

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  1. W. SCHAUMANN
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SCHAUMANN, W. Influence of Atropine and Morphine on the Liberation of Acetylcholine from the Guinea Pig's Intestine. Nature 178, 1121–1122 (1956). https://doi.org/10.1038/1781121b0

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