Abstract
IN 1954, a group of workers reported on a new tumour-inhibitory substance1. This substance, called azaserine, also possessed antibacterial activity against numerous microbial species2. Chemically, this substance is O-diazoacetyl-L-serine3. It has been reported that azaserine is a profound inhibitor of formate incorporation into the nucleic acids4. Since the role of nucleic acid synthesis is particularly important in Endamoeba histolytica 5,6 the effect of azaserine on the amœbæ was studied.
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References
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NAKAMURA, M. Amœbicidal Action of Azaserine. Nature 178, 1119–1120 (1956). https://doi.org/10.1038/1781119b0
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DOI: https://doi.org/10.1038/1781119b0
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