Abstract
IN the course of the preparation of various chloroethylamines which are potential tumour growth-inhibitors we have examined 2-chloroethyl methane-sulphonate (I, X = Cl; CB 1506) as a reagent for the direct conversion of an amino-group into a chloroethylamino-group under mild conditions. It occurred to us that amino-groups in biological systems might be chloroethylated in vivo by this compound. For this reason the methanesulphonate (I, X = Cl) was tested against a number of transplanted animal tumours. 
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HADDOW, A., Ross, W. Tumour Growth-inhibitory Alkyl Sulphonates. Nature 177, 995–996 (1956). https://doi.org/10.1038/177995a0
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DOI: https://doi.org/10.1038/177995a0
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