Remission of Rat Lymphocytic Leukæmia 8 following Intravenous Administration of 4-(p-Diethylaminostyryl)quinoline Dihydrochloride

Abstract

EARLIER studies¹ indicated that oral administration of certain styryl quinolines resulted in complete absorption of lymphoma 8 growing in inbred rats of the strain of its spontaneous origin. The neo-plastie cells of this lymphoma appear in the bloodstream of the host animal as early as 18 hr. after subcutaneous implantation² and increase greatly, in some instances, to as many as 100,000 per c.mm. in the eighteen to twenty-one days before death of the rat. Intraperitoneal injection of 1 ml. of this lymphogenous blood into normal rats of the same strain produces a lymphocytic blood picture which bears a resemblance to certain types of clinical lymphocytic leukæmia. This lymphocytic leukæmia (rat lymphocytic leukæmia 8) is always fatal within twelve to twenty days. In view of their anti-lymphoma action, it seemed of interest to determine whether styryl quinolines, intravenously administered, would have any effect on this type of leukæmia in rats.