Abstract
THE failure of rabbits to develop antibody to bovine serum albumin when injected with this antigen at an early age was recently reported by Hanan and Oyama1. Similar results have been reported by Buxton2, who found there was no antibody response to killed Salmonella pullorum in fowls after they had been exposed to this organism as embryos and young chicks. The studies of Hanan and Oyama1 suggest that the responses to closely related antigens may also be impaired in rabbits that exhibit inhibition. If, however, rabbits that failed to develop antibodies to one antigen were capable of producing antibodies to a closely related one, the value of such antisera in systematic serology and similar fields would be apparent. Preliminary results of pre- and post-natal exposure of rabbits to parenteral administration of whole chicken serum are reported in this communication.
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References
Hanan, R., and Oyama, J., J. Immunol., 73, 49 (1954).
Buxton, A., J. Gen. Microbiol., 10, 398 (1954).
Burnet, M., Brit. Med. J., No. 4481, 189 (1954).
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DOWNE, A. Inhibition of the Production of Precipitating Antibodies in Young Rabbits. Nature 176, 740–741 (1955). https://doi.org/10.1038/176740a0
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DOI: https://doi.org/10.1038/176740a0
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