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Glutamine as an Accelerator of Chondroitin Sulphate Synthesis

Nature volume 176, pages 601–602 (1955)Cite this article

Abstract

THE sulphate exchange of chondroitin sulphuric acid can easily be studied in vitro in surviving slices of cartilage suspended in a Krebs–Ringer-bicarbonate solution containing 35S-labelled sulphate1,2. The influence of various factors on this reaction, which is of an enzymatic nature, has been studied in this department. In the course of the work, it was noted that small amounts of a liver homogenate added to the suspending medium produced a remarkable stimulation of the sulphate incorporation into chondroitin sulphuric acid. As reported in a preliminary paper3, this effect was found to be due to the presence in the liver of a thermostable, dialysable factor.

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References

  1. Boström, H., and Månsson, B., Arkiv Kemi, 6, 23 (1953).

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Authors and Affiliations

  1. Chemistry Department II, Karolinska Institutet, Stockholm

    HARRY BOSTRÖM, LENNART RODÉN & ANDERS VESTERMARK

Authors
  1. HARRY BOSTRÖM
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  2. LENNART RODÉN
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  3. ANDERS VESTERMARK
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BOSTRÖM, H., RODÉN, L. & VESTERMARK, A. Glutamine as an Accelerator of Chondroitin Sulphate Synthesis. Nature 176, 601–602 (1955). https://doi.org/10.1038/176601a0

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