Abstract
IN general, the blood-group antigens appear to form a permanent part of the human red cell in vivo; they persist throughout the life of the cell not only under normal conditions, but also after transfusion into the circulation of a recipient with a different set of antigens. Moreover, antigens characteristic of the recipient do not appear upon the transfused cells. These statements have been shown to be true for the ABO, MNS, Rh, Lutheran, Kell, Duffy and Kidd antigens; but the Lewis antigens have not previously been investigated in this respect.
Similar content being viewed by others
Article PDF
References
Mourant, A. E., Nature, 158, 237 (1946).
Andresen, P. H., Acta Path. Microbiol. Scand., 24, 616 (1947).
Grubb, R., and Morgan, W. T. J., Brit. J. Exp. Path., 30, 198 (1949).
Grubb, R., Rev. d'Hem., 5, 268 (1950).
Stormont, C., Proc. U.S. Nat. Acad. Sci., 35, 232 (1949).
Brendemoen, O. J., J. Lab. Glin. Med., 34, 538 (1949).
Brendemoen, O. J., Acta Path. Microbiol. Scand., 31, 579 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SNEATH, J., SNEATH, P. Transformation of the Lewis Groups of Human Red Cells. Nature 176, 172 (1955). https://doi.org/10.1038/176172a0
Issue Date:
DOI: https://doi.org/10.1038/176172a0
This article is cited by
-
Observations on the Lewisa and Lewisb activity of erythrocytes
International Journal of Legal Medicine (1995)
-
Purification and properties of the ?-3/4-l-fucosyltransferase released into the culture medium during the growth of the human A431 epidermoid carcinoma cell line
Glycoconjugate Journal (1993)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.