Abstract
ALTHOUGH the effects of anaphylaxis and chemical histamine releasers are similar and mainly attributable to histamine release, the mechanism by which the release occurs in the two cases is fundamentally different. We have found that lack of oxygen and also inhibitors of oxidative and glycolytic metabolism have a powerful inhibitory action on the release of histamine in anaphylaxis but enhance its release by compound 48/80 (a condensation product of p-methoxyphenyl-ethyl-methylamine and formaldehyde) and octylamine.
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Parrot, J.-L., C.R. Soc. Biol., Paris, 136, 361 (1942).
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Mongar, J. L., and Schild, H. O., J. Physiol., 126, 44p (1954).
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MONGAR, J., SCHILD, H. Inhibition of Histamine Release in Anaphylaxis. Nature 176, 163 (1955). https://doi.org/10.1038/176163b0
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DOI: https://doi.org/10.1038/176163b0
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