Abstract
PORTER1 found that both the anti-ovalbumin antibody and the non-specific γ-globulin of rabbit serum contained the same single N-terminal amino-acid, namely, alanine. Hughes and Sinex2 consider this “amazing”; and seeing that the serum component called γ-globulin is a family of proteins that includes diverse antibodies and possibly protein with other functions, and has been shown to be heterogeneous by various physico-chemical criteria, this result is certainly not inevitable.
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References
Porter, R. R., Biochem. J., 46, 473 (1950).
Hughes, W. L., and Sinex, F. M., “Ann. Rev. Biochem.”, 23, 187 (1954).
Sanger, F., Biochem. J., 39, 507 (1945).
Putnam, F. W., J. Amer. Chem. Soc., 75, 2785 (1953).
McFadden, M. L., and Smith, E. L., J. Amer. Chem. Soc., 75, 2784 (1953).
Porter, R. R., Biochim. Biophys. Acta, 2, 105 (1948).
Smith, E. L., J. Biol. Chem., 164, 345 (1946).
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ORLANS, E. The N-Terminal Amino-Acid of Rabbit Gamma-Globulin and Antibody. Nature 175, 728 (1955). https://doi.org/10.1038/175728a0
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DOI: https://doi.org/10.1038/175728a0
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