Abstract
DIFFERENCES in the fate of thyroglobulin labelled with iodine-131 appearing in the plasma of patients treated with therapeutic doses of radioactive iodide1 have led us to study the metabolism of thyroid protein in animals. In rats, doses of radioactive iodide sufficient to destroy the thyroid gland result in the appearance of labelled thyroglobulin in the plasma. The protein is speedily removed, radioactive thyroxine and iodide appearing in the plasma. Administration of rat thyroglobulin to normal rats or to rats in which the gland has been previously eliminated by radioactive iodide gives the same pattern of events (Table 1).
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References
Brown, F., and Jackson, H., Biochem. J., 56, 399 (1954).
Lerman, J., J. Clin. Invest., 19, 555 (1940).
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BROWN, F., JACKSON, H. Metabolism of Thyroglobulin labelled with Iodine-131. Nature 175, 472–473 (1955). https://doi.org/10.1038/175472b0
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DOI: https://doi.org/10.1038/175472b0
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