Abstract
FOLLOWING early experiments1, it was considered that the mouse was one of the animals most resistant to tuberculosis. More recently, it has been found that the mouse could be readily infected by the intravenous route2, or by inhalation3, but it was still considered to be highly resistant to subcutaneous infection. It was found4 that c57 black mice, maintained on a deficient diet and infected intranasally, were as sensitive as the guinea pig for the detection of small numbers of tubercle bacilli. The small lesions produced in the lungs had to be examined microscopically, as non-specific lesions sometimes occurred; in tuberculous lesions there were, of course, numerous bacilli.
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References
Cobbett, L., “The Causes of Tuberculosis” (Cambridge, 1917).
Stewart, G. T., Brit. J. Exp. Path., 31, 5 (1950). Pierce, C., Dubos, R. J., and Schaefer, W. B., J. Exp. Med., 97, 189 (1953).
Glover, R. E., Brit. J. Exp. Path., 25, 141 (1944).
Gray, D. F., and Mattinson, M. W., Amer. Rev. Tuberc., 65, 572 (1952). Gray, D. F., Clarke, B. L., and Mattinson, M. W., Amer. Rev. Tuberc., 69, 92 (1954).
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FRANCIS, J. Use of the Mouse for Detection of Small Numbers of Tubercle Bacilli. Nature 175, 344–345 (1955). https://doi.org/10.1038/175344a0
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DOI: https://doi.org/10.1038/175344a0
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