Abstract
RECIPROCAL interference between strains of the three recognized types of poliomyelitis virus has been reported by Ledinko1, using roller-tube cultures of monkey testicular tissue. In her experiments, both the ‘interfering’ and the ‘excluded’ virus were fully cytopathogenic, and there was no suggestion of any mutual inhibition of their degenerative effects on the cells. Prevention of growth of the second virus, as shown by titration in the presence of type-specific antiserum against the first, was apparently the result of pre-emptive infection and subsequent destruction of susceptible cells by the first virus. The purpose of this communication is to describe a further example of interference among poliomyelitis viruses, in which a more direct recognition of the effect was made possible by the peculiar cytopathogenic behaviour of the interfering virus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ledinko, N., Federation Proc., 12, 451 (1953). See also, Melnick, J. L., in “Advances in Virus Research”, 1, 232 and 234 (Academic Press, New York, 1953).
Morgan, J. F., Morton, H. J., and Parker, R. C., Proc. Soc. Exp. Biol., N.Y., 73, 1 (1950).
Casals, J., Olitsky, P. K., and Anslow, R. O., J. Exp. Med., 94, 111 (1951).
Sabin, A. B., Winsser, J., and Hennessen, W. A., Collected Summaries of Papers presented at the VIth International Congress of Microbiology, 2, No. 470 (Rome, September 1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LE BOUVIER, G. Interference and Cell Protection by Poliomyelitis Virus in Tissue Culture. Nature 174, 649–650 (1954). https://doi.org/10.1038/174649b0
Issue Date:
DOI: https://doi.org/10.1038/174649b0
This article is cited by
-
Increased resistance of SV40 transformed human amnion cells to poliovirus infection
Archiv f�r die gesamte Virusforschung (1970)
-
Virological aspects of Coxsackie virus infections
Archiv f�r die gesamte Virusforschung (1963)
-
Biologische und pathogenetische Eigenschaften in Gewebekultur isolierter Coxsackie-Stämme
Zeitschrift für Hygiene und Infektionskrankheiten (1961)
-
Interference phenomena between ECHO virus types 1, 2, 7 and 11
Archiv f�r die gesamte Virusforschung (1961)
-
Multiplication of poliovirus in tissue cultures previously infected with other enteroviruses
Archiv f�r die gesamte Virusforschung (1961)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
