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Control of Mitotic Activity

Abstract

THE mechanically active phase of nuclear reproduction is closely associated with the appearance of polymerized deoxyribonucleic acid (DNA) on the chromosomes. Furthermore, it has been shown that cells containing little or no DNA do not divide1 and that continued synthesis of this form of nucleic acid is essential for further nuclear reproduction2. The actual synthesis of DNA appears to take place during interphase2,3, although it is not yet fully established whether it is produced directly from the store of ribose nucleic acid (RNA) or from other sources. But whatever the processes involved, any modification leading to the disappearance or reduction of deoxyribonucleic acid from the cell will act as a mechanism whereby nuclear division may be regulated.

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ROWLANDS, D. Control of Mitotic Activity. Nature 173, 828–829 (1954). https://doi.org/10.1038/173828a0

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