Abstract
AMONG the numerous compounds obtained by modifying the chemical molecular structure of Para-amino-salicylic acid, our attention has been directed to 4-ammo-6-hydroxy-iso-phthalic acid1, especially concerning the discordant opinions in respect of its antitubercular activity. In fact, while Bavin et al.2 have found an activity corresponding to that of the para-amino-salicylic acid, according to Beyerman and Alberda1 the compound should be 2–5 times less active than para-amino-salicylic acid.
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van der Stelt, C., and Nauta, Th., Pharm. Weekbl., 85, 476 (1950). Beyerman, H. C., and Alberda, G., Recueil, 69, 1021 (1950). Doub, L., Schaefer, J. J., and Walker, C. T., Abstr. of Papers, 118th Meeting, Amer. Chem. Soc., 6M (1950).
Bavin, E. M., Drain, D. J., Seiler, M., and Seymour, D. E., J. Pharm. and Pharmacol., 4, 844 (1952).
Beyerman, H. C., and Wielaert, G. L. G., Recueil, 71, 1213 (1952).
Noelting, E., and Collin, A., Ber., 17, 265 (1884). Robertson, A., and Robinson, R., J. Chem. Soc., 2201 (1927). Pearman, S. A., J. Chem. Soc., 119, 717 (1921).
Maltese, R., Gazz. Chim. Ital., 37, ii, 284 (1907).
Spaeth, E., Klager, K., and Schloesser, C., Ber., 64, 2210 (1931).
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CHECCACCI, L., LOGEMANN, W., PISTOIA, C. et al. Presumed Antitubercular Activity of 4-Amino-6-Hydroxy-iso-Phthalic Acid. Nature 173, 588 (1954). https://doi.org/10.1038/173588a0
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DOI: https://doi.org/10.1038/173588a0
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