Abstract
RECENTLY, Iseki and Masaki1 reported what they believed to be a new isoagglutinin in the serum of a 27-year old patient who had six pregnancies all ending in abortions at two to five months. The serum of this group A, Rh-positive patient agglutinated the blood of each one of a hundred random bloods of groups O and A, independent of their Rh status. The serum, however, failed to react with its own red cells and the red cells of three out of four siblings. On the basis of absorption experiments, we believed that we were dealing with a single antibody which appeared to be different from anti-k (anti-Cellano) and anti-e, both of which give very high incidence of positive reactions.
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References
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ISEKI, S., MASAKI, S. & LEVINE, P. A Remarkable Family with the Rare Human Isoantibody Anti-Tja in Four Siblings: Anti-Tja and Habitual Abortion. Nature 173, 1193–1194 (1954). https://doi.org/10.1038/1731193a0
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DOI: https://doi.org/10.1038/1731193a0
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